Machine Learning Uncovers Food- and Excipient-Drug Interactions
نویسندگان
چکیده
منابع مشابه
General Considerations Modes of Drug Decomposition Drug–excipient Interactions
Excipients are included in dosage forms to aid manufacture, administration or absorption. Other reasons for inclusion concern product differentiation, appearance enhancement or retention of quality.1 They rarely, if ever, possess pharmacological activity and are accordingly loosely categorized as ‘inert.’ However, excipients can initiate, propagate or participate in chemical or physical interac...
متن کاملFood and Drug Interactions
Natural foods and vegetal supplements have recently become increasingly popular for their roles in medicine and as staple foods. This has, however, led to the increased risk of interaction between prescribed drugs and the bioactive ingredients contained in these foods. These interactions range from pharmacokinetic interactions (absorption, distribution, metabolism, and excretion influencing blo...
متن کاملDrug-excipient interactions in ketoprofen: a vibrational spectroscopy study.
Ketoprofen (3-benzoyl-alpha-methylbenzeneacetic acid) is a widely used nonsteroidal anti-inflammatory drug (NSAID), always administered in the form of drug-excipient physical mixtures (PMs). The occurrence of possible interactions between ketoprofen and two commonly used excipients-lactose (LAC) and polyvinylpyrrolidone (PVP)-was evaluated, through vibrational spectroscopy techniques [both Rama...
متن کاملFood-drug interactions.
The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction) or another disease the person has (drug-disease interaction). A drug interaction is a situation in which a substance affects the activity of a drug, ...
متن کاملDrug-Excipient Interactions: Case Studies and Overview of Drug Degradation Pathways
The objective of the current research article is to provide a comprehensive review of excipients impact on the stability of the drug product and their implications during the product development. Recent developments in the understanding of the degradation pathways further impact methodologies used in the pharmaceutical industry for potential stability assessment. The formation of drug excipient...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2020
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2020.02.094